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Conversely, anti-inflammatory cytokines such as IL-10 and TGF- can significantly ameliorate joint inflammation and facilitate cartilage damage repair

Although rhGH-treatment partly restored reduced expression of GHR and IGF-1 in the kidneys and resulted in profound metabolic effects, including improved weight gain and lower urea serum levels, there was no difference with respect to renal recovery and mortality compared to placebo-treated controls

This release of calcium may potentially trigger the secretion of hGH from the somatotroph cells in the anterior pituitary gland

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