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Glutathione biosynthesis occurs in several, but not in all eukaryotic cell types through a well-coordinated and feedback-modulated process that needs one essential amino acid, cysteine, and two others, glutamic acid and glycine, that most cells can synthesize themselves from the intermediates of core metabolism

This deficiency can manifest as fatigue, brain fog, or reduced exercise tolerance, all of which undermine weight loss motivation

Chronic stress has a range of negative effects, including hormone imbalance, leaky gut, blood sugar imbalances and a rapid reduction of glutathione reserves