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or Polycitra a combination of citric acid, potassium citrate, and sodium citrate) has been used as an oral medication to help maintain plasma bicarbonate levels within the reference range (or alternatively very large doses of bicarbonate may be used)

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In the context of metabolic disorders, numerous preclinical and clinical studies indicate that CGA improves insulin sensitivity, regulates blood glucose levels, lowers blood pressure, and positively affects the lipid profile by reducing LDL cholesterol and triglyceride levels while increasing HDL cholesterol [87,88,89,90,91,92,93,183]