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Yao S, Wang Z, Li L

ROS are mainly derived from the process of electron transfer from the mitochondrial electron transport chain complex to O 2 , with complexes I and II producing in the mitochondrial matrix and complex III producing in the matrix and membrane interstitium, which is the precursor of most ROS

Moreover, we confirmed that the conjugate is degraded in vitro by incubation under high concentrations of glutathione (Extended Data Fig

Indeed, the concentrations of all ETC complex inhibitors required to inhibit 50% of cancer cell growth were significantly reduced when cells were exposed to 5FU (Fig