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Systemic side effects are less common but can include headaches, dizziness, or nausea shortly after the injection

Much of the supporting research summarized in peer-reviewed literature relies on animal studies, such as GLP-1 receptor-knockout mice and rodent injection trials, rather than large-scale human trials, and peptide-based drugs overall are described as rarely used in real-world patient care because of lingering questions about safety, effectiveness, and inadequate insurance coverage

He combined HCG injection with a very low-calorie diet (500 calories per day) and claimed that his patients experienced rapid weight loss without feeling hungry or weak

(2001) published the foundational preclinical study in Endocrinology demonstrating that the hGH C-terminal fragment inhibits adipogenesis in 3T3-L1 cells, establishing the mechanistic rationale for AOD-9604