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While it is well known that enhanced insulin sensitivity and low insulin levels are associated with an improved survival, there is evidence showing that attenuation of the growth hormone/IGF-1 axis may have beneficial effects in extending lifespan in humans

Rosaneli CF, Bighetti AE, Antonio MA, Carvalho JE, Sgarbieri VC

We start with the dominant symptom, monitor response, and add therapies in a staged fashion, always weighing metabolic and oncologic risks

Mood Instability and Emotional Dysregulation: The restoration of neurotransmitter synthesis via the methylation cycle also directly impacts emotional well-being