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Description

Ras-selective lethal small molecule 3 (RSL3) directly inhibits the activity of GPX4 by covalently binding to selenocysteine, which is located at the active site of GPX4, thereby inducing ferroptosis (Ma et al., 2022a)

doi: 10.1016/j.smrv.2023.101844, 18

Seven years later, the FDA closed its investigation without establishing causality, a $2.6 billion lawsuit has raised serious questions about how that investigation was triggered, and the peer-reviewed literature remains genuinely contested