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The reason retatrutide and the approved GLP-1s are titrated up over months is side effects: in the Phase 2 trial, jumping to high doses without titration nearly doubled gastrointestinal side effects for the same weight loss (The Lancet, 2023)

Some studies showed lowered ghrelin levels in patients with major depressive disorder (MDD) compared to healthy controls 17,18 while other studies found higher levels 19,20,21 , or no significant difference 22,23,24,25

Finally, this study identifies the most influential countries, institutions, authors, and journals through visual analysis, which can guide junior researchers in identifying mentors and partners when submitting contributions, selecting appropriate journals and institutions, and seeking suitable national collaborations to make informed decisions on the allocation of funds and resources

The FDA issued a safety alert in April 2025 noting 32 adverse event reports (20192024) including erectile dysfunction, depression, and suicidal ideation