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The statistical analysis of the hydrophilic fraction (Fig 2A and A) yielded a regression model with high-quality parameters (R 2 = 0.99 [goodness of fit] and Q 2 = 0.94 [power in goodness of prediction] (23), CV-ANOVA test, P = 0.0006), and a clear class discrimination (Fig 2A)

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a NNMT inhibitor such as a cation of Formula I or IA, or otherwise disclosed herein one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

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