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Djoko et al., 2012)

The gut microbiota also influences DA levels in the frontal cortex and striatum of rodents, and perturbations of the dopaminergic system are associated with mood-related disorders and cognitive dysfunction

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These studies have also brought to light their potential as a rich and unexplored source for new therapeutic targets and agents through multiple avenues, including direct targeting of the catalytic sites, controlling disease-associated proteinprotein interactions and developing novel biologics from the secreted ARS proteins or their parts