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To evaluate the ability of molecules to interfere with aggregation of hCC while informing about cellular toxicity, cells were generated that produce and secrete WT and L68Q-hCC producing high-molecular weight complexes formed from the mutant protein

This powerful effect was particularly important during the peak outbreak of COVID-19 where it was suggested as a possible supplement to help suppress the widespread inflammation often leading to organ failure

The clinical problem is delivery

The presence of increased levels of oxidized dopamine and lower glucocerebrosidase activity, in turn promotes S accumulation ( Although direct interconnections between the release of pro-inflammatory cytokines and S accumulation have yet to be established, altered pro-inflammatory cells in experimental PD models suggest that inflammation and S dysregulation are closely interconnected (Tan et al., 2020)