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Outline known safety data and tolerability of GHK-Cu in humans Clinical reports note mild local reactions for topical application and rare systemic adverse events at low doses

Metformin Evidence: Long-term studies (including the TAME trial) show improved cardiovascular health, reduced inflammation, and lower all-cause mortality in diabetics

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Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development