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Although there are several known risk factors for depression that were not included in this analysis, to function as a confounder, these factors would also need to be associated with elevated body temperature

In clinical studies targeting obesity, particularly in the phase 3 trials based on the SURPASS program, tirzepatide demonstrated outstanding weight reduction benefits, with some patients achieving a weight loss of up to 22.5%

The results revealed that 347 genes were down-regulated and 573 genes were up-regulated following 1D228 treatment (Red dots indicate up-regulated genes in the group, blue dots indicate down-regulated genes in the group, and gray dots indicate non-significant differentially expressed genes)