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Consequently, UNC10088 promotes ubiquitination of the NSD2 PWWP1 domain by SCF FBXO22 in the presence of different combinations of ubiquitin-carrying enzymes (UCEs), E2s (UBE2D2, UBE2L3, UBE2R2) and the ARIH-type of RBR (ARIH1) (Fig