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Enhancing synaptic plasticity, stimulating intrinsic cytoprotective pathways, and delivering neurotrophic support are necessary, but insufficient steps

Under cellular stress conditions, both erythroid 2-related factor 2 (Nrf2) and activating transcription factor 4 (ATF4) can influence ferroptosis by regulating the transcription of SLC7 A11, albeit through distinct mechanisms and regulatory elements

J Clin Investig 111(6):869876 Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE (2003) Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

The fruit of the Nigella sativa plant contains three to six carpels, each of which contains seeds that turn black when mature