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The AR is continuously activated in CRPCs, which can regulate the expression of glutamine uptake-regulated molecules and metabolism, and proto-oncogene-expressed proteins in CRPCs can induce the same metabolic changes [10, 11]

Dynamic transcriptional responses to stress, mediated by factors like ATF4 and XBP1, also play a central role by balancing adaptive mechanisms with apoptotic pathways (Diane et al., 2024)