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Both peptides go into solution at the 1:1 mass ratio, so working-concentration aliquots carry the combined formulation rather than either peptide independently

Acknowledgments The authors would like to thank the researchers whose work was included in this study

After two rounds of evolution, we identified two biosensors that were highly selective for S -THP (STHP2) or R -THP (RTHP2), showing a 51-fold or 16-fold difference in EC 50 between the enantiomers, respectively (Fig

A switch from L-peptides to DRI peptides will not change this scenario for the S-shaped A 42 fibrils, however, it will still lead to a smaller number of hydrogen bonds in the DRI-fibril than seen in the L-fibril