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10.1016/j.clnu.2019.01.020 26

Cytosolic Ca 2+ is taken up by a voltage-dependent anion-selective channel and mitochondrial calcium uniporter channels, leading to accumulation of Ca 2+ in the mitochondrial matrix

Although the proposed vicious cycle remains a working hypothesis requiring further validation, understanding this interplay may help identify novel biomarkers, stratify patients by metabolic phenotype, and guide precision therapies for HF

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