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In vitro and in silico studies on lignan secoisolariciresinol diglucoside

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The development of highly selective and structurally optimized CYP51A1 inhibitorsor context-specific modulatorscould provide valuable therapeutic strategies, particularly in hormone-sensitive cancers, immune regulation, and metabolic diseases

Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release