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In rodent studies, degeneration may also be applicable to chronic debility, but more often it is used to reflect acute or chronic cytological alterations with characteristic morphological features

Notably, in the setting of high-frequency and prolonged sympathetic activation such as during acute myocardial ischemia, additional sympathetic co-transmitters other than norepinephrine (NE) are co-released from sympathetic post-ganglionic efferent fibers, including ATP, galanin and neuropeptide Y (NPY) (Herring 2015)

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Clonal selection may facilitate the initial survival of malignant cells during anticancer therapy, permitting a minority of cancer cells to acquire additional drug-resistant mutations, thereby facilitating disease progression