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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Shan F., Liu L., Li L., Wang W., Bi Y., Li M

There is some evidence to suggest that such retrotranslocation of calreticulin from the ER to the cytosol occurs via the nucleus, where it may interact with proteins with nuclear export signals and exit the nucleus in complex with nuclear proteins (115)

Finally, curcumin has also the ability to regulate autophagy, reducing the expression of key autophagy-related genes such as Beclin-1, ATG5, and LC3II, while increasing B cell lymphoma 2 (bcl-2), thereby improving colitis [509]

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