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The exact mechanisms of the increased permeability for Ca 2+ are unknown, however it has been proposed that PHB can act as a natural Ca 2+ ionophore (Elustondo et al., 2+ uniporter is expected to generate a current equivalent to ~50 pA per single mitochondrion (Kirichok et al., 2+ flux in the mitochondria of intact cells is estimated to be in the order of 0.005 pA

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10.1038/srep45266 57 OwonikokoT