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Distinct protocols of ethanol administration result in different effects on brain phospholipid composition, ranging from a reduction in some saturated FA (12:0, 14:0, and 16:0) and a rise in 18:0 without diet effects (42)

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At the same time, a large data set of mRNA bulk data from the Lung Tissue Research Consortium (Gene Expression Omnibus database accession number GSE47460) (24) did not present significant differences in the expression of NAD + -consuming enzymes (Supplemental Figure 1B) but a highly significant decrease in CYB5R3 expression in IPF when compared with healthy lungs (Supplemental Figure 1C)