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Label the vial: Record the date of reconstitution and the calculated concentration

Methodological quality was assessed using the Newcastle-Ottawa Scale for cohort studies

JCI Insight 6 , e153732 (2021)

If the distribution of confounding factors differs in the two arms, explicative regression analysis will be performed in which the dependent variable will be the normalisation of the serum vitamin B12 concentration, and the independent variable will be the treatment group