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cellular energy and mitochondrial health : NAD + (100 mg/mL injectable solution, SIRT1-7 and PARP-1 sirtuin activator, mitochondrial biogenesis and DNA repair) and glutathione (GSH, a major intracellular antioxidant, involved in phase II detoxification and mitochondrial protection)

Standardized protocol development should establish optimal pressure parameters (2.0-2.5 ATA appears favorable based on current evidence), treatment duration (60-90 minutes/session), and session frequency (daily versus alternate day) while addressing implementation challenges such as cost-effectiveness analyses and specialized training requirements for combined CPR-HBO delivery systems (Figure 4)