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When demand risesthrough inflammation, toxin exposure, or intense physiologic stresscells can burn through antioxidant capacity faster than it is restored

Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig

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