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To overcome the immunosuppressive effect of MDSCs in ACT, docetaxel was used in a murine colon and breast cancer model to downregulate the recruitment and overall increase of MDSCs in the neoplastic microenvironment, thus boosting the effects of ACT mediated by T cells ( CTX is a second-generation semisynthetic taxane that is used to bypass the resistance induced by docetaxel and paclitaxel

10.1097/MEG.0000000000000458 43 HassaneinT.McclainC

This modulation is evidenced by the suppression of pro-inflammatory cytokines (IL-17, IL-2, IL-21) and the enhancement of anti-inflammatory cytokines (IL-4, IL-10, TGF-), suggesting that uric acid may play a crucial role in the cross-talk between macrophages and CD4 + T cells

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