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CPO-PEG 2 -biotin (final concentration = 150 M) in DMSO (5% total volume) was then added and the reaction was left to incubate for a further 2 h at room temperature

It is well established that calcitriol, after forming a complex with its receptor, vitamin D receptor (VDR) and heterodimerizing with the retinoic acid receptor (RXR), directly inhibits preproPTH gene transcription by binding to a specific DNA response element (VDRE) located in the 5-flanking region of the gene

The number of significantly altered metabolites increased to 26 in the mild disease group, 14 and 12 with increased and decreased values, respectively

Williams, A novel role for vitamin B12: Cobalamins are intracellular antioxidants in vitro, Free Radical Biology and Medicine, Volume 47, Issue 2, 15 July 2009, Pages 184-188, ISSN 0891-5849, J