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Cell pellets were resuspended in 50 mL of Lysis Buffer (50 mM NaH 2 PO 4 pH 7.6, 150 mM NaCl, 20 M PLP), sonicated (1 s on/off alternatively at 40 W for 30 min) and centrifuged (14,000 g for 40 min at 4 C)

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MATERIAL AND METHODS Trial design This double-blind randomized placebo-controlled trial was carried out on adult patients (aged 18 years and over) with a diagnosis of MDD referred to the medical centers of Babol University of Medical Sciences, during the year 20192020

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