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Large population studies show that adults with lower carotenoid consumption tend to report shorter sleep duration, suggesting that antioxidant status may influence healthy sleep patterns.34 A smaller randomized trial tested 12mg of astaxanthin daily for eight weeks and found improvements in several sleep parameters, along with reduced perceived stress compared to placebo.4 The authors proposed that astaxanthins antioxidant and neuroprotective activity including its ability to cross the bloodbrain barrier could help stabilize oxidative stress in brain regions involved in regulating sleep and mood

[DOI] [PMC free article] [PubMed] [Google Scholar] [47].May JM, Mendiratta S, Hill KE, Burk RF, Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase, J

10.1093/emboj/21.6.1301 EMBO J

Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin and other indicators of vitamin B status in the elderly