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Further optimization of the timing, dose, and duration of IGF-1R mAb treatment is warranted in order to maximize benefits while minimizing risks, particularly given recent evidence that transient administration of other drugs can have persistent benefits on age-related outcomes 43

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Pairing a local repair signal with a systemic one is the rationale behind the combination

Fondaparinux sodium was initiated 6 2 hours (mean 6.25 hours) after surgery in 94% of patients, and enoxaparin sodium was initiated 12 hours to 24 hours (mean 21 hours) after surgery in 96% of patients