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For example, asymptomatic IBD patients, as well as their healthy first-degree relatives, exhibit increased gut permeabilityfollowed by the later onset of CD for the second group suggesting that early barrier leakiness might be a trigger for disease development [41, 42]

It is expected that membrane structure associates to mitochondrial dynamics and metabolism, we will address this topic in the next sections

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Aboudalle I, Kantarjian HM, Ravandi F, Jabbour EJ, Daver NG, Estrov ZE, Andreeff M , Ferrajoli A, DiNardo CD, Pemmaraju N, Naqvi K, Jain N, Pelletier SG, Garcia-Manero G, Cortes JE, Kadia TM