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Description

WADA official source

On the one hand, mitochondrial dysfunction can promote EMT process and lead to tubulointerstitial fibrosis of early DN 31

The synergy claim is mechanistic, derived from the three peptides acting on different nodes of overlapping pathways (VEGF, NF-kB, ECM remodeling)

a ) the carboxyl group makes electrostatic interactions with Arg439 and Arg929 of IRAP and b ) phenyl ring of the phenylacetic acid group makes pi-stacking interactions with Tyr961