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We also examined the effect of RNK06395 on the viability of several cancer cell lines using the CTG assay, which demonstrated that RNK06395 could inhibit cell viability and induce cell death with an improved IC 50 compared to that of RNK06138 (Fig

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It has been shown that lower GI pressure is significantly elevated in patients with GERD compared to healthy subjects, which may be a major factor in the development of GERD ( Lactobacillus acidophilus and Bifidobacterium bifidum in promoting the migration of MMCs and facilitating small intestinal transit, lower GI motility ( 4.7 The products of microbiome (SCFAs) indirectly protect the esophagus from multiple pathways and have potential for the treatment of GERD Microorganisms in the colon are capable of fermenting indigestible food components and consuming prebiotics to produce short-chain fatty acids (SCFAs) ( Figure 2 )