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Furthermore, studies on the production stability of rCHO cell lines generated using GS-based MSX selection, which is one of the most important issues for the practical use of a cell line in industry, have not been fully substantiated yet 11,17,20,21

Volume 466

Format Pack of 30 sticks

According to the protein misfolding avoidance hypothesis, natural selection disfavors the misfolding of highly expressed proteins, thereby constraining their evolution to minimize cytotoxicity 38