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Therefore, the effectiveness of the use of the transporter-mediated prodrug approach for the brain delivery of drugs with brain extracellular targets is questionable

Blocking the HGF/c-Met signaling pathway inhibits PNI in pancreatic cancer To further validate the c-Met-mediated finding in PNI, the lentiviral vector c-Met-shRNA was used to suppress c-Met expression in pancreatic cancer cell lines