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Taken together, our results provide a mechanistic rationale for KEAP1NRF2-targeted interventions in MIBC and highlight how abrogating tumor antioxidant defenses and cell plasticity can synergize with conventional chemotherapy to yield superior anticancer effects

By the end of two years of treatment, very disabled early course patients treated with CET demonstrated significant improvements in social functioning, employment, major role functioning, work readiness, activities of daily living, and instrumental task performance

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Such self-diagnostic tools could reduce healthcare system burden and facilitate earlier detection with greater convenience