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Another small clinical trial, comprising six patients with GBM who underwent multiple cycles of BBB disruption using MRgFUS to enhance the penetration of TMZ chemotherapy, also found that MRgFUS is safe and well-tolerated without any significant long-term complications at 1-year follow-up [119]

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For acquisition, cleared samples were imaged in a sagittal orientation (left lateral side up) on a light-sheet microscope (Miltenyi Blaze) equipped with a sCMOS camera and LVMI-Fluor 4 objective lens equipped with a 6-mm working distance dipping cap

SIRT5 regulates the NRF2/HO-1 pathway in a ROS-dependent manner to inhibit cisplatin (CDDP)-induced DNA damage, thereby promoting CDDP resistance in ovarian cancer (OC) [77]