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As a consequence, exposure of human spermatozoa to intrinsically- or extrinsically- generated reactive oxygen intermediates can result in a state of oxidative stress characterized by peroxidative damage to the sperm plasma membrane and DNA damage to the mitochondrial and nuclear genomes

The extracellular matrix (ECM) is a network of extracellular macromolecules, enzymes, collagen, and other biomolecules that provide support for surrounding cells

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