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10.1016/j.apsb.2025.05.010 25 ChoiH

Downregulation of glyoxalase system does not result in MG accumulation Lower activity of the glyoxylate system through ROS deactivation and/or hypoxia-driven downregulation would be expected to lead to local MG accumulation in tumor tissue, especially since solid tumors are known to exhibit a high level of glycolytic dependency 56