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The mechanistic rationale builds on earlier work by Kraus and colleagues in Nature (2014), in which adipocyte-specific NNMT knockdown protected mice from diet-induced obesity, establishing NNMT as a metabolic-disease target candidate [2]

Worse, degraded peptides can form aggregates or byproducts that may trigger immune responses or injection site reactions

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However, in rare casessuch as patients with kidney disease or specific hereditary disorders related to vitamin B12 metabolismhigh doses or inappropriate use could potentially cause complications