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Mutations accumulate in mtDNA perhaps because the DNA is not packaged by histones and because mtDNA is positioned within the mitochondrion alongside the electron transport system and its byproducts, namely oxygen free radicals

However, this is a mixed observation, and careful monitoring in research protocols is key

Glutathione (GSH) is a tripeptide, gamma-glutamyl-cysteinyl-glycine, which readily undergoes oxidation to form a disulphide-linked hexapeptide, oxidised glutathione, generally abbreviated to GSSG The table below shows the concentrations of GSH and GSSG in red cells from 10 control subjects, and Samuel W, before and after incubation with acetylphenylhydrazine

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