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The microneedling evidence base is for delivering established hair compounds a randomized pilot of microneedling plus minoxidil (PMID 23960389) reported greater hair-count change than minoxidil alone, and a 2025 study of copper-peptide microneedling for androgenetic alopecia (PMID 40225275) reported measurable regrowth neither study tested AHK-Cu as a standalone topical

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The enzymes DNA methyltransferases catalyze the transfer of methyl groups, derived from SAM, to the CpG islands in the promoter region of a gene, preventing the interaction of this region with the transcriptional machinery and consequently blocking gene expression (Triantaphyllopoulos et al., 2016) ( Figure 1 )