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When researchers knocked out beta-3 receptors in mice, the chronic weight loss effects of AOD-9604 disappeared confirming this receptor is essential for its long-term fat-burning action (Ng et al., 2001)

Gautier CA, Erpapazoglou Z, Mouton-Liger F, Muriel MP, Cormier F, Bigou S, Duffaure S, Girard M, Foret B, Iannielli A, Broccoli V, Dalle C, Bohl D, Michel PP, Corvol J-C, Brice A, Corti O (2016) The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations

Experience low energy levels that hinder physical activity

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