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In summary, the interplay between iron, -syn, ROS, and NM forms a toxic feedback loop that perpetuates oxidative stress, impairs iron homeostasis, and promotes ferroptosis and neurodegeneration (268)

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[1] [12] For most people, doses up to 2 mg (2000 micrograms) daily are unlikely to cause harm according to NHS guidance, as B12 is water-soluble and excess is typically excreted in urine