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If this were to operate in the endoplasmic reticulum, collateral oxidation of the glutathione redox pool would also be avoided since the primary oxidation of cliient proteins occurs via QSOX, and not oxidized PDI

They are particularly beneficial for vegetarians and vegans (since B12 is found primarily in animal products), older adults with reduced absorption capacity, individuals with digestive conditions such as Crohn's disease or celiac disease, and anyone who has had gastric bypass surgery

It is to build a strategy around the individual, the objective, the clinical data, and whether the approach is actually working

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