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CJC-1295 (a growth hormone-releasing hormone analog) amplifies pulsatile GH release from the pituitary, while MK-677 (ibutamoren) acts as a ghrelin receptor agonist to stimulate continuous GH secretion

This fact is evident, for example, in many human-specific diseases such as Alzheimer's, Parkinson's, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, cystic fibrosis, and hemophilia A, which do not appear in animals (202, 203)