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Drug Test Anal, 5 (11-12), 850-852

The growth-promoting effects of growth hormone include muscle tissue hypertrophy (which may be desired by some but represents an anabolic effect), bone growth and remodeling (problematic after growth plates close), organ enlargement with chronic supraphysiologic doses (cardiac hypertrophy, acromegaly features), connective tissue proliferation (potentially contributing to joint pain and carpal tunnel syndrome), and cellular proliferation that may support tumor growth in susceptible individuals

And in most cases, they were not approved. According to the FDAs own website, the drug approval process is complex and time consuming, involving years of clinical trials, evaluation of research and inspection of facilities where the drugs will be manufactured

Hair is left feeling silky, hydrated and easier to detangle, with a smooth finish and natural-looking shine