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Elevated estrogen can cause water retention, mood swings, and even gynecomastia if youre prone to it

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By inhibiting the production of isoprenoids from the mevalonate pathway, statins prevent the activation of the ras homolog gene family, member A (RhoA)/rho-associated protein kinase (ROCK) in renal macrophages, thereby reducing the assembly of the NLRP3 inflammasome and subsequent production of IL-1/IL-18 (121, 122)