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Modulation of IMS redox pathways influences E GSH [IMS] only to a minor extent Due to its proximity to the respiratory chain, the IMS glutathione pool might be influenced by the activity of the respiratory chain, for example, by release of reactive oxygen species (ROS)

Critical factors of ferroptosis in glioma Ferroptosis follows multiple pathways and involves pivotal factors that are regulated by many different regulators

hlund, D

Treatment with propargylglycine (PAG) [16], a pharmacological inhibitor of the key enzyme in the transsulfuration pathway that catalyzes the hydrolysis of cystathionine into cysteine, cystathionine -lyase (CSE), was sufficient to sensitize two MYCN -amplified NB cell lines to system Xc-inhibition ( Fig